lipopolysaccharide
[대역어] 지질다당질
[용어속성] Compound
[용어속성] Compound
Proteomic analysis and identification reveal the anti-inflammatory mechanism of clofazimine on lipopolysaccharide-induced acute lung injury in mice
Article
[키워드] acute lung injury
acute respiratory distress
acute respiratory distress syndrome
alleviate
Analysis
Anti-inflammatory
anti-inflammatory property
anti-inflammatory response
ARDS
CFZ
Clofazimine
coronavirus disease
COVID-19
Critical
decrease
disease
Diseases
distress
down-regulate
histological change
hyperimmune response
IL-1β
immune
IMPROVE
increasingly
Infectious disease
Inflammatory
information
inhibit
involved
lipopolysaccharide
LPS
lung
Lung injury
Macrophage
macrophages
mechanism
mice
Molecular biology
pathway
pharmacological mechanism
potential molecular
profile
proliferation
protective effect
Protein
protein expression
Proteomic analysis
proteomics
proteomics.
Pulmonary edema
Quantitative
Signal transduction
Signaling
significantly
survival rate
syndrome
therapeutic strategy
TNF-α
[DOI] 10.1007/s00011-022-01623-w PMC 바로가기
[DOI] 10.1007/s00011-022-01623-w PMC 바로가기
SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Article
[키워드] aggregate
aggregation
analyses
assays
bacterial lipopolysaccharide
binding
boost
COVID-19
demonstrated
endotoxins
Evidence
gel
High dose
Inflammation
Invasion
lipopolysaccharide
LPS
Microscopy
Molecular simulation
oligomers
peptide
predicted
Protein
protein-aggregation
Proteins
S protein
SARS-CoV-2
SARS-CoV-2 spike protein
sequence
Spike protein
spike protein.
triggered
virus
[DOI] 10.1002/1873-3468.14490 PMC 바로가기
[DOI] 10.1002/1873-3468.14490 PMC 바로가기
Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine storm
Glycyrrhetinic acid : Covid-19 사이토 카인 폭풍의 치료를위한 잠재적 약물
Article
Published on
Journal: Phytomedicine : international journal of phytother
[Category] 신약개발, 유전자 메커니즘, 치료법, 치료제,
Journal: Phytomedicine : international journal of phytother
[Category] 신약개발, 유전자 메커니즘, 치료법, 치료제,
[키워드] Analysis
caused
core genes
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 cytokine storm
cytokine
Cytokine storm
database
docking result
effective
ESR1
experiment
experimental results
Experimental verification
experiments
Glycyrrhetinic acid
Health
Human
IL-17
IL6
immune
in vitro
in vivo
Infection
Inflammatory
inhibit
inhibitory effect
Interaction
Intervention
KEGG
Kyoto
lack
lipopolysaccharide
MAPK3
mechanism
molecular docking
molecule
network
network pharmacology
Network pharmacology.
Ontology
pathway
pathway enrichment
PPAR signaling
PPARG
PPI
PPI network
predict
protein-protein interaction
Proteins
PTGS2
R language
Research
screened
signaling pathway
signaling pathways
significantly
target gene
Target genes
targets
TNF
TNF signaling
treat
Treatment
triggered
Venn diagram
was performed
[DOI] 10.1016/j.phymed.2022.154153 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.phymed.2022.154153 PMC 바로가기 [Article Type] Article
Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease
Reviews
[키워드] Affect
arteries
Artery
atherosclerotic
atherosclerotic plaques
cardiovascular disease
cell types
changes in
circulation
clinical study
demonstrated
described
dysfunction
endothelial cells
endotoxaemia
Factor
Gram-negative bacteria
Gut
IMPROVE
Inflammation
intestinal
leukocytes
lipopolysaccharide
LPS
mechanism
membrane
Patient
plaque instability
Platelet
pro-inflammatory status
promote
review
risk
risk factor
suggested
systemic
systemic inflammation
therapeutic
thrombus formation
translocation
[DOI] 10.1038/s41569-022-00737-2 [Article Type] Reviews
[DOI] 10.1038/s41569-022-00737-2 [Article Type] Reviews
Clinical progress in MSC-based therapies for the management of severe COVID-19
Mini review
[키워드] MB-MSCs
Menstrual blood-derived Mesenchymal Stromal Cells
3-dioxygenase
ACE2angiotensin converting enzyme 2
acute graft-versus-host disease
acute respiratory distress syndrome
Adipose Tissue derived Mesenchymal Stromal Cells
admadministration
administration
alanine aminotransferase
Allo-MSCsAllogeneic Mesenchymal Stromal Cells
Alloallogeneic
Allogeneic
Allogeneic Mesenchymal Stromal Cells
ALTalanine aminotransferase
angiotensin converting enzyme 2
anti-inflammatory property
ARDS
ARDSacute respiratory distress syndrome
Aspartate aminotransferase
ASTaspartate aminotransferase
AT-MSCsAdipose Tissue derived Mesenchymal Stromal Cells
AT2type 2 alveolar cells of the lungs
BALFbronchoalveolar lavage fluid
BM-MSCsbone marrow derived MSCs
body weight
bone marrow derived MSCs
Bronchoalveolar lavage fluid
bwBody weight
C-reactive protein
cAMPcyclic adenosine monophosphate
candidate
CDcluster of differentiation
Cell
clinical
clinical trial
cluster of differentiation
complex
conducted
Coronavirus disease 2019
coronavirus disease of 2019
COVID-19
COVID-19Coronavirus disease of 2019
CRPC-reactive protein
cyclic adenosine monophosphate
cytokine
Daewoong Pharmaceutical’s Mesenchymal Stromal Cells
DCsdendritic cells
dendritic cells
driven by
DSCsPlacenta-derived decidua stromal cells
DW-MSCsDaewoong Pharmaceutical’s Mesenchymal Stromal Cells
EVsextracellular vesicles
Extracellular vesicles
Fas ligands
Fas-LFas ligands
FDAFood and Drug Administration
FGFfibroblast growth factor
fibroblast growth factor
Food and Drug Administration
forkhead box P3 +
FOXP3 +forkhead box P3 +
G-CSFgranulocyte colony-stimulating factor
Gal-1galectin-1
Gal-3galectin-3
Gal-9galectin-9
galectin-1
galectin-3
Galectin-9
GM-CSFgranulocyte macrophage-colony stimulating factor
granulocyte colony-stimulating factor
granulocyte macrophage-colony stimulating factor
growth factor
GvHDacute graft-versus-host disease
HB-AT-MSCsHope Biosciences autologous adipose-derived mesenchymal stromal cells
HdHigh dose
hepatocyte growth factor
HGFhepatocyte growth factor
High dose
HLAHuman leukocyte antigen
Hope Biosciences autologous adipose-derived mesenchymal stromal cells
human leukocyte antigen
ICUIntensive Care Unit
IDOIndoleamine 2
IFN-γinterferon-γ
IL-10interleukin-10
IL-1interleukin-1
IL-1βinterleukin-1β
IL-2 receptor
IL-2interleukin-2
IL-2RIL-2 receptor
IL-4interleukin-4
IL-6interleukin-6
IL-7Interleukin 7
IL-7interleukin-7
IL-8interleukin 8
IL-9interleukin
IL1-αinterleukin 1-α
IL1-βinterleukin 1-β
IL1RaInterleukin-1 receptor antagonist
immune dysregulation
immunological
immunomodulatory
IMVInvasive mechanical ventilation
Indoleamine 2
inducible protein 10
inflammatory process
inhalation
INHinhalation
intensive care unit
interferon-γ
interleukin
interleukin 1-α
interleukin 1-β
Interleukin 7
interleukin 8
interleukin-1
Interleukin-1 receptor antagonist
interleukin-10
interleukin-1β
interleukin-2
Interleukin-4
interleukin-6
interleukin-7
intravenous
Invasive mechanical ventilation
IP-10inducible protein 10
IVintravenous
keratinocyte growth factor
KGFkeratinocyte growth factor
lactate dehydrogenase
LDHlactate dehydrogenase
LdLow dose
lipopolysaccharide
low dose
LPSlipopolysaccharide
major histocompatibility complex
management
MAPKmitogen-activated protein kinase
MCP-1monocyte chemoattractant protein-1
Mesenchymal stromal cell
Mesenchymal stromal cells
MHCMajor Histocompatibility Complex
microRNA
miRNAmicroRNA
MIS-Cmultisystem inflammatory syndrome in children
mitogen-activated protein kinase
monocyte chemoattractant protein-1
MSCs
MSCsmesenchymal stromal cells
multisystem inflammatory syndrome in children
nanovesicles
National Institutes of Health
natural
NETsNeutrophil Extracellular Traps
Neutrophil extracellular traps
NF-κBnuclear factor-kappa B
NIHNational Institutes of Health
nitric oxide
NKnatural
NONitric Oxide
nuclear factor-kappa B
NVsnanovesicles
occur
PD-1programmed cell death protein 1
PD-L1programmed death ligand-1
PGE2prostaglandin E2
pharmacological management
PL-MSCsPlacental-derived Mesenchymal Stromal Cells
Placenta-derived decidua stromal cells
placental expanded
Placental-derived Mesenchymal Stromal Cells
PLX-PADplacental expanded
programmed cell death protein 1
programmed death ligand-1
prostaglandin E2
protein spike
public health
reactive oxygen species
Regulatory T cell
Respiratory failure
RFrespiratory failure
ROSreactive oxygen species
SARS-CoV-2severe acute respiratory syndrome coronavirus 2
Secretome
severe acute respiratory syndrome coronavirus 2
severe COVID-19
Severe respiratory distress
signal transducer activators of transcription-3
Sprotein spike
STAT3signal transducer activators of transcription-3
syndrome
TGF-β1transforming growth factor-β1
TGFtransforming growth factor
the cytokine storm
the disease
therapeutic
therapy
TLRtoll-like receptors
TNF-α-stimulating gene 6
TNF-αtumor necrosis factor-α
TNFTumor Necrosis Factor
Toll-like receptors
transforming growth factor
transforming growth factor-β1
treat
Tregregulatory T cell
TSG-6TNF-α-stimulating gene 6
tumor necrosis factor
tumor necrosis factor-α
type 2 alveolar cells of the lungs
UC-MSCsumbilical cord derived MSCs
umbilical cord derived MSCs
vascular endothelial growth factor
VEGFvascular endothelial growth factor
Wharton’s Jelly–derived Mesenchymal Stromal Cells
WJ-MSCsWharton’s Jelly–derived Mesenchymal Stromal Cells
[DOI] 10.1016/j.cytogfr.2022.07.002 [Article Type] Mini review
[DOI] 10.1016/j.cytogfr.2022.07.002 [Article Type] Mini review
In Vitro Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19
다클론 자극에 대한 1차 인간 T 세포 및 단핵구의 체외 노출은 손상된 세포 면역 반응을 표시하고 심각한 COVID-19를 발생시키는 기초 감수성을 나타냅니다
Article
[키워드] (PD-1
acute respiratory syndrome
acute respiratory syndrome coronavirus
Alpha
analyzed
Anosmia
anti-CD3
Antibody titer
Antibody titers
basal
baseline characteristics
biochemical
blood sample
Blood samples
CD14
CD16
CD4+
CD8+ T cell
CD8+ T cells
Cellular immune response
cellular immunity
classical
classical monocytes
clinical recovery
conducted
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
COVID-19 progression
disease
display
distress
drug
Evidence
exposure
expression
Fever
Follow-up
headache
healthy volunteer
Human
Humoral immunity
hypoxia
IFN-alpha
IFN-gamma
IL-2
immune function
immune response
Immunoglobulin
Immunoglobulin G
Impaired
in vitro
interferon
interleukin
interleukin-2
Invasive mechanical ventilation
lipopolysaccharide
Mild
mild cases
monocyte
monocyte subsets
monocyte.
Monocytes
Neutralizing
no difference
no differences
non-classical monocyte
Non-classical monocytes
not differ
participant
Patient
PD-1
Pneumonia
polyclonal
predisposition
programmed cell death
programmed cell death protein
prospective cohort study
Protein
receiving
Registered
required
respiratory
respiratory distress
response
S1 protein
SARS-CoV-2
SARS-COV-2 infection
serum titer
Severe case
severe cases
severe COVID-19
severity
significantly
subset
Symptom
T cell
T cells
virus
worsening
[DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
[DOI] 10.3389/fimmu.2022.897995 PMC 바로가기 [Article Type] Article
Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells
스쿠텔라레인은 RAW264.7 세포에서 NF-κB/MAPK 신호 전달 경로를 통해 LPS 유도 염증을 억제합니다
Article
[키워드] addition
Anti-inflammatory
can be used
Cell
cells
Chinese
composed
Compound
COVID-19
Cyclooxygenase
cytokine
Cytokines
determine
diploid
endotoxin
ERK
expression
Extracellular
family
Gram-negative bacteria
Helicase
IL-1β
Immune cell
immune cells
immune system
Inflammation
Inflammatory
inflammatory disorder
inflammatory disorders
inhibit
interleukin
interleukin-1β
involved
IκBα
JNK
kinases
lipopolysaccharide
LPS
LPS-induced inflammation
MAPK
mechanism
mitogen
NF-kB
NF-кB
nitric oxide
nitric oxide synthase
no effect
nuclear
outer membrane
p65
pathway
Pathways
pro-inflammatory mediators
proinflammatory mediators
protein kinase
required
SARS Coronavirus
SCU
scutellarein
scutellarein (SCU).
secretion
shown
stimulate
stimulated
TNF-α
Topic
treat
Treatment
Tumor
tumor necrosis
tumor necrosis factor
tumor necrosis factor-α
was reduced
western blot
[DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/molecules27123782 PMC 바로가기 [Article Type] Article
Lung targeted liposomes for treating ARDS
ARDS 치료를 위한 폐 표적 리포솜
Article
[키워드] accumulate
accumulation
acute respiratory distress
acute respiratory distress syndrome
Administered
administration
alveolar
approach
ARDS
BAL
Bronchoalveolar lavage
C57BL/6
characterized
combined treatment
COPD
COVID-19
COVID-19 infections
cysteine
cytokine secretion
distal
DPPC
drug
Efficiency
encapsulation
endotracheal
exhibited
Gas exchange
Hypoxemia
IL-1β
IL-6
impair
infections
Inflammation
Inflammatory marker
inflammatory markers
intravenous
intravenously
lipid composition
Lipid nanoparticles
lipopolysaccharide
Liposome
lung
lung damage
Lung diseases
lung disorders
lung endothelial
lung epithelial
Lung inflammation
Lungs
Macrophage
macrophages
marker
medication
Methylprednisolone
mice
mortality rate
mortality rates
MPS
mucolytic agent
Mucus
N-acetyl cysteine
NAC
nanoparticle
Nanotechnology
nitric oxide
outcome
Patient
penetration
provided
pulmonary
Pulmonary.
reached
reduce
reducing
Region
respiratory
respiratory distress
Respiratory distress syndrome
secretion
steroid
syndrome
therapeutic
therapeutic effect
therapeutic efficacy
TNFα
Treatment
Treatment outcome
were assessed
[DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.jconrel.2022.03.028 PMC 바로가기 [Article Type] Article